Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein-60 secretion and protein arginine methyltransferase-1 in fibroblasts

Q Sun, L Fang, M Roth et al European Respiratory Journal 2019 54: 1900300; DOI: 10.1183/13993003.00300-2019 Bronchial thermoplasty (BT) is the only therapy that provides a lasting reduction in airway wall remodelling but it’s mechanism of action is not well Continue Reading →

NEW GUIDELINE: Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

F.Holguin, J.C. Cardet, K.F. Chung et al European Respiratory Journal 2020 55: 1900588; DOI: 10.1183/13993003.00588-2019 This guideline includes thefollowing clinical recommendations for the management of severe asthma 1) using anti-interleukin (IL)-5 and anti-IL-5 receptor α for severe uncontrolled Continue Reading →

Improving Lung Function in Severe Heterogenous Emphysema with the Spiration Valve System (EMPROVE). A Multicenter, Open-Label Randomized Controlled Clinical Tria

Gerard J. Criner, Antoine Delage , Kirk Voelker et al https://doi.org/10.1164/rccm.201902-0383OC  AJRCCM 200 (11) Dec 01, 2019 Summary: In this multicenter, open-label, randomized, controlled trial, subjects aged 40years or older with severe, heterogeneous Continue Reading →

Improving Lung Function in Severe Heterogenous Emphysema with the Spiration Valve System (EMPROVE). A Multicenter, Open-Label Randomized Controlled Clinical Trial

Gerard J. Criner , Antoine Delage, Kirk Voelker et al https://doi.org/10.1164/rccm.201902-0383OC Methods: In this multicenter, open-label, randomized, controlled trial, subjects aged 40 years or older with severe, heterogeneous emphysema were randomized 2:1 to SVS Continue Reading →