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Category Archives: Journal Club

NEW GUIDELINE: Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic COPD (ATS)

Posted on August 14, 2020 by Lunglead

AIM: Noninvasive ventilation (NIV) is used for patients with chronic obstructive pulmonary disease (COPD) and chronic hypercapnia. However, evidence for clinical efficacy and optimal management of therapy is limited. METHOD: We Continue Reading →

Posted in Journal Club

Inhibition of mast cells: a novel mechanism by which nintedanib may elicit anti-fibrotic effects

Posted on August 14, 2020 by Lunglead

Overed-Sayer C, Miranda E, Dunmore R, et al   Thorax Published Online First: 24 July 2020.    AIM: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease which presents a grave prognosis for diagnosed patients. Continue Reading →

Posted in Journal Club

Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome

Posted on August 14, 2020 by Lunglead

Rhodes C J, Otero-Nuñez P, Wharton J et al Am J Respir CCMed 202 (4) 586–594, Aug 15 2020 AIM: Idiopathic and heritable pulmonary arterial hypertension (PAH) are rare but Continue Reading →

Posted in Journal Club

NEW GUIDELINE: Diagnosis of Hypersensitivity Pneumonitis in Adults (ATS)

Posted on August 14, 2020 by Lunglead

Raghu G, Remy-Jardin M, Ryerson C J et al  Am J Respir Crit C M  202 3 p 36-69, Aug 1, 2020 AIM: This guideline addresses the diagnosis of hypersensitivity pneumonitis Continue Reading →

Posted in Journal Club

Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness: a systematic review and meta-analysis

Posted on August 14, 2020 by Lunglead

Brunwasser S, Snyder B M, Driscoll A J et al Lancet Respir Med 2020 (8) 795–806 AIM: It is unclear whether lower respiratory tract infections (LRTIs) with respiratory syncytial virus Continue Reading →

Posted in Journal Club

A major genetic determinant of autoimmune diseases is associated with the presence of autoantibodies in hypersensitivity pneumonitis

Posted on August 14, 2020 by Lunglead

Buendía-Roldán I, Santiago-Ruiz L, Pérez-Rubio G et al  Eur Respir J 2020 56 1901380 AIM: Hypersensitivity pneumonitis is an immune-mediated disease triggered by exposure to organic particles in susceptible individuals. Continue Reading →

Posted in Journal Club

Metagenomics Reveals a Core Macrolide Resistome Related to Microbiota in Chronic Respiratory Disease

Posted on August 14, 2020 by Lunglead

Aogain M, Lau K, Cai Z et al Am J Respir Crit Care Med Vol 202 (3) 433–447, Aug 1 2020 AIM: Long-term antibiotic use for managing chronic respiratory disease Continue Reading →

Posted in Journal Club

TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target

Posted on August 14, 2020 by Lunglead

Yu, J., Zhou, D., Yang, X. et al.    Nature Commun 11, 3660 (2020) AIM: High expression or aberrant activation of epidermal growth factor receptor (EGFR) is related to tumor progression and therapy Continue Reading →

Posted in Journal Club

Serial CT analysis in idiopathic pulmonary fibrosis: comparison of visual features that determine patient outcome

Posted on August 14, 2020 by Lunglead

Jacob J, Aksman L, Mogulkoc N, et al.   Thorax 2020;75:648-654. AIM: Patients with idiopathic pulmonary fibrosis (IPF) receiving antifibrotic medication and patients with non-IPF fibrosing lung disease often demonstrate rates of annualised forced vital capacity (FVC) decline Continue Reading →

Posted in Journal Club

Implementation of a computer-guided consultation in the assessment of suspected obstructive sleep apnoea syndrome

Posted on August 14, 2020 by Lunglead

Chakrabarti B, Lewis-Burke N, Pearson M et al   ERJ Open Res 2020; 6: 00362-2019 AIM: To describe implementation of a computer-guided consultation (CGC) clinical decision support system in the assessment of suspected obstructive Continue Reading →

Posted in Journal Club

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