Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein-60 secretion and protein arginine methyltransferase-1 in fibroblasts

Q Sun, L Fang, M Roth et al European Respiratory Journal 2019 54: 1900300; DOI: 10.1183/13993003.00300-2019 Bronchial thermoplasty (BT) is the only therapy that provides a lasting reduction in airway wall remodelling but it’s mechanism of action is not well Continue Reading →

NEW GUIDELINE: Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

F.Holguin, J.C. Cardet, K.F. Chung et al European Respiratory Journal 2020 55: 1900588; DOI: 10.1183/13993003.00588-2019 This guideline includes thefollowing clinical recommendations for the management of severe asthma 1) using anti-interleukin (IL)-5 and anti-IL-5 receptor α for severe uncontrolled Continue Reading →

Improving Lung Function in Severe Heterogenous Emphysema with the Spiration Valve System (EMPROVE). A Multicenter, Open-Label Randomized Controlled Clinical Tria

Gerard J. Criner, Antoine Delage , Kirk Voelker et al https://doi.org/10.1164/rccm.201902-0383OC  AJRCCM 200 (11) Dec 01, 2019 Summary: In this multicenter, open-label, randomized, controlled trial, subjects aged 40years or older with severe, heterogeneous Continue Reading →

Improving Lung Function in Severe Heterogenous Emphysema with the Spiration Valve System (EMPROVE). A Multicenter, Open-Label Randomized Controlled Clinical Trial

Gerard J. Criner , Antoine Delage, Kirk Voelker et al https://doi.org/10.1164/rccm.201902-0383OC Methods: In this multicenter, open-label, randomized, controlled trial, subjects aged 40 years or older with severe, heterogeneous emphysema were randomized 2:1 to SVS Continue Reading →

COPD

2017. Diagnosis, Management and Prevention of COPD (GOLD) Updated Global Initiative for Obstructive Lung Disease (GOLD) strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease. 2015. Pulmonary Continue Reading →