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NEW GUIDELINE: Long-Term Noninvasive Ventilation in Chronic Stable Hypercapnic COPD (ATS)

Posted on August 14, 2020 by Lunglead

AIM: Noninvasive ventilation (NIV) is used for patients with chronic obstructive pulmonary disease (COPD) and chronic hypercapnia. However, evidence for clinical efficacy and optimal management of therapy is limited. METHOD: We Continue Reading →

Posted in Journal Club

Inhibition of mast cells: a novel mechanism by which nintedanib may elicit anti-fibrotic effects

Posted on August 14, 2020 by Lunglead

Overed-Sayer C, Miranda E, Dunmore R, et al   Thorax Published Online First: 24 July 2020.    AIM: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease which presents a grave prognosis for diagnosed patients. Continue Reading →

Posted in Journal Club

Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome

Posted on August 14, 2020 by Lunglead

Rhodes C J, Otero-Nuñez P, Wharton J et al Am J Respir CCMed 202 (4) 586–594, Aug 15 2020 AIM: Idiopathic and heritable pulmonary arterial hypertension (PAH) are rare but Continue Reading →

Posted in Journal Club

NEW GUIDELINE: Diagnosis of Hypersensitivity Pneumonitis in Adults (ATS)

Posted on August 14, 2020 by Lunglead

Raghu G, Remy-Jardin M, Ryerson C J et al  Am J Respir Crit C M  202 3 p 36-69, Aug 1, 2020 AIM: This guideline addresses the diagnosis of hypersensitivity pneumonitis Continue Reading →

Posted in Journal Club

Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness: a systematic review and meta-analysis

Posted on August 14, 2020 by Lunglead

Brunwasser S, Snyder B M, Driscoll A J et al Lancet Respir Med 2020 (8) 795–806 AIM: It is unclear whether lower respiratory tract infections (LRTIs) with respiratory syncytial virus Continue Reading →

Posted in Journal Club

A major genetic determinant of autoimmune diseases is associated with the presence of autoantibodies in hypersensitivity pneumonitis

Posted on August 14, 2020 by Lunglead

Buendía-Roldán I, Santiago-Ruiz L, Pérez-Rubio G et al  Eur Respir J 2020 56 1901380 AIM: Hypersensitivity pneumonitis is an immune-mediated disease triggered by exposure to organic particles in susceptible individuals. Continue Reading →

Posted in Journal Club

Metagenomics Reveals a Core Macrolide Resistome Related to Microbiota in Chronic Respiratory Disease

Posted on August 14, 2020 by Lunglead

Aogain M, Lau K, Cai Z et al Am J Respir Crit Care Med Vol 202 (3) 433–447, Aug 1 2020 AIM: Long-term antibiotic use for managing chronic respiratory disease Continue Reading →

Posted in Journal Club

TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target

Posted on August 14, 2020 by Lunglead

Yu, J., Zhou, D., Yang, X. et al.    Nature Commun 11, 3660 (2020) AIM: High expression or aberrant activation of epidermal growth factor receptor (EGFR) is related to tumor progression and therapy Continue Reading →

Posted in Journal Club

Serial CT analysis in idiopathic pulmonary fibrosis: comparison of visual features that determine patient outcome

Posted on August 14, 2020 by Lunglead

Jacob J, Aksman L, Mogulkoc N, et al.   Thorax 2020;75:648-654. AIM: Patients with idiopathic pulmonary fibrosis (IPF) receiving antifibrotic medication and patients with non-IPF fibrosing lung disease often demonstrate rates of annualised forced vital capacity (FVC) decline Continue Reading →

Posted in Journal Club

Implementation of a computer-guided consultation in the assessment of suspected obstructive sleep apnoea syndrome

Posted on August 14, 2020 by Lunglead

Chakrabarti B, Lewis-Burke N, Pearson M et al   ERJ Open Res 2020; 6: 00362-2019 AIM: To describe implementation of a computer-guided consultation (CGC) clinical decision support system in the assessment of suspected obstructive Continue Reading →

Posted in Journal Club

Mepolizumab in a population with severe eosinophilic asthma and corticosteroid dependence: results from a French early access programme

Posted on July 14, 2020 by Lunglead

Camille Taillé, Pascal Chanez, Gilles Devouassoux et al European Respiratory Journal  2020  55:  1902345;  DOI: 10.1183/13993003.02345-2019 AIM: Mepolizumab was available in France as part of an early access programme for Continue Reading →

Posted in Journal Club

GUIDELINE: ARTP statement on pulmonary function testing

Posted on July 14, 2020 by Lunglead

Karl Peter Sylvester, Nigel Clayton, Ian Cliff et al. BMJ Open Respiratory Research 2020;7:e000575.  5th July 2020 doi: 10.1136/bmjresp-2020-000575 The ARTP have provided within this document the most up-to-date and Continue Reading →

Posted in Journal Club

The natural history of progressive fibrosing interstitial lung diseases

Posted on July 14, 2020 by Lunglead

Kevin K. Brown, Fernando J. Martinez, Simon L.F. Walsh et al. Eur Respir J 2020 55:2000085; published ahead of print 2020   doi:10.1183/13993003.00085-2020 AIM: Idiopathic pulmonary fibrosis (IPF) is, by definition, Continue Reading →

Posted in Journal Club

Association of Azithromycin Use With Cardiovascular Mortality

Posted on July 14, 2020 by Lunglead

Zaroff, J.G., Cheetham T.C, Palmetto N et al. JAMA Netw Open. 2020;3(6):e208199. doi:10.1001/jamanetworkopen.2020.8199 AIM: Azithromycin, a macrolide, is one of the most commonly prescribed antibiotics in the US, with an Continue Reading →

Posted in Journal Club

Association of Noninvasive Oxygenation Strategies With All-Cause Mortality in Adults With Acute Hypoxemic Respiratory Failure.

Posted on July 14, 2020 by Lunglead

Bruno L. Ferreyro, Federico Angriman, Laveena Munshi et al. JAMA. 2020;324(1):57–67. doi:10.1001/jama.2020.9524 AIM: To compare the association of non-invasive oxygenation strategies with mortality and endotracheal intubation in adults with acute hypoxemic Continue Reading →

Posted in Journal Club

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